Welcome to the Radhakrishnan lab website at Northwestern University. The lab is interested in the mechanistic aspects of eukaryotic transcription regulation at the molecular level. A broad range of transcription factors and coregulator proteins important for normal cellular physiology and development are presently under investigation.
Solution NMR spectroscopy and macromolecular crystallography are the principal approaches employed in these studies, although diverse biochemical, biophysical, and informatic approaches are also used. NMR and x-ray crystallography afford atomic-level descriptions of macromolecules. The choice of approach is geared towards their respective strengths: x-ray crystallography for the ability to provide detailed pictures of large, complex systems, and NMR spectroscopy for smaller systems that also feature dynamically disordered segments that are resistant to crystallization. NMR is also used for discovering novel functions and for gaining dynamical insights.
Outstanding NMR, crystallography, and computational resources exist within the department. Super high-field NMR instruments and synchrotron sources in the area are also readily accessible. The department provides a highly interactive, intellectually stimulating environment. Evanston is a suburb of Chicago and is among the most desirable places to live in the country.